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Evaluation of the biocompatibility of poly (benzimidazobenzophenanthroline)(BBL) polymer films with living cells

AFM probes used in the publication

Tap300Al-G
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Tap300Al-G

Tapping Mode AFM Probe with Aluminum Reflective Coating
Coating: Reflective Aluminum
Tip Shape: Rotated
AFM Cantilever:
  • F
    300 kHz
  • C
    40 N/m
  • L
    125 µm

Abstract

The integration of organic electronic materials with biological systems to monitor, interface with, and regulate physiological processes is a key area in the field of bioelectronics. Central to this advancement is the development of cell-chip coupling, where materials engineering plays a critical role in enhancing biointerfacing capabilities. Conductive polymers have proven particularly useful in cell interfacing applications due to their favorable biophysical and chemical properties. However, n-type conductive polymers remain underexplored, primarily due to their limited long-term stability. In this study, it is demonstrated that the conductive polymer poly(benzimidazobenzophenanthroline) (BBL), commonly used in organic electronic devices, can effectively support neuronal cell viability and spreading, both as a bare cell culture material and when coated with exracellular matrix proteins. This work provides a preliminary validation of BBL's potential for future integration into bioelectronic devices and in biointerfacing.
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